Fig. 2

(A) Volcano plot, (B) Heat map and (C) Gene expression signatures reflect hypoxic state of HAL-treated HCC xenografts. (A) Differential gene expression analysis of Control versus HAL-treated HCC xenografts, (D) GSEA analysis showing enrichment of MSigDB Hallmark pathways in HAL-treated versus Control samples. GSEA plot of genes up (D) and down (E) regulated during hypoxia from Elvidge et al.