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Table 2 CT Findings of ILA and Their Association with EGFR mutation

From: Prognostic and predictive value of interstitial lung abnormalities and EGFR mutation status in patients with non-small cell lung cancer

Estimation of extent

EGFR (+)

EGFR (-)

Pvalue

Subcategories

22

87

<0.001

 Subpleural fibrotic ILA

2 (9.10)

55 (63.22)

 

 Subpleural nonfibrotic ILA

10 (45.45)

18 (20.69)

 

 Non-subpleural ILA

10 (45.45)

14 (16.09)

 

Total scorea

1.23±0.53

1.28±0.48

0.580

Distribution

  

0.012

 Subpleural

17 (77.27)

79 (90.80)

 

 Peribronchovascular

5 (22.73)

3 (3.45)

 

 Mixed

0

5 (5.75)

 

Score of ILA findingsa

   

 Upper GGO

4.11±9.90

4.01±6.80

0.154

 Middle GGO

7.61±10.41

10.13±10.98

0.068

 Lower GGO

14.89±14.06

17.23±15.41

0.433

 Upper reticulation

2.61±6.70

7.99±9.19

<0.001

 Middle reticulation

3.75±4.41

12.66±11.67

<0.001

 Lower reticulation

8.11±6.45

19.53±15.32

<0.001

 Upper honeycombing

0.00±0.00

1.28±3.63

0.068

 Middle honeycombing

0.11±0.53

2.83±5.67

0.001

 Lower honeycombing

0.41±1.46

7.50±12.56

<0.001

 Tractive bronchiectasis

1.91±3.90

7.15±5.46

<0.001

  1. Unless otherwise indicated, data are numbers of patients, with the percentages in parentheses
  2. ILA Interstitial lung abnormality, EGFR Epidermal growth factor receptor
  3. aData are means ± standard deviations