Table 4 Univariate and multivariate Cox analysis for overall survival

Sex (male vs. female)

3.066 (1.366–6.884)

0.007

1.091 (0.367–3.243)

0.875

Smoking status (current or former smoker vs. never)

2.121 (1.101–4.087)

0.025

1.384 (0.595–3.220)

0.450

ILA subcategory (subpleural fibrotic ILA vs. non-fibrotic ILA)

2.065 (1.156–3.690)

0.014

1.282 (0.678–2.424)

0.444

EGFR status (mutated vs. wild)

0.165 (0.059–0.466)

0.001

0.169 (0.042–0.675)

0.012

TNM staging (III-IV vs. I-II)

16.414 (2.258-119.292)

0.006

14.819 (1.936-113.407)

0.009

Histologic findings (adenocarcinoma vs. non-adenocarcinoma)

0.301 (0.156–0.581)

<0.001

0.612 (0.293–1.281)

0.193

Pleural traction (+)

0.503 (0.285–0.889)

0.018

0.802 (0.428–1.503)

0.491

Pleural fluid (+)

3.740 (2.005–6.977)

<0.001

2.796 (1.347–5.803)

0.006