Histogram analysis of multiple diffusion models for predicting advanced non-small cell lung cancer response to chemoimmunotherapy

Table 5 Diagnostic performance of signifcant parameters and the combined model obtained by using whole tumor analysis

Parameters	AUC	Cutoff value	Youden Index	Sensitivity	Specificity	PPV	NPV	Accuracy	P
ADC
75th	0.661	≤ 1.845	0.2730	85.37	41.94	66.04	68.43	66.65	0.0149
Mean	0.712	≤ 1.55	0.3611	78.05	58.06	71.11	66.67	69.43	0.0009
Median	0.649	≤ 1.39	0.3761	63.41	74.19	76.46	60.53	68.06	0.0296
Dk
75th	0.640	≤ 1.65	0.3021	46.34	83.87	79.16	54.17	62.52	0.0315
90th	0.662	≤ 1.962	0.2880	70.73	58.06	69.04	60.00	65.27	0.0116
Mean	0.672	≤ 1.483	0.3525	70.73	64.52	72.50	62.50	68.05	0.0084
Dslow
10th	0.730	≤ 0.817	0.4823	80.49	67.74	76.74	72.41	74.99	0.0002
25th	0.660	≤ 1.013	0.3446	73.17	61.29	71.42	63.34	68.05	0.0194
75th	0.759	≤ 1.599	0.5224	78.05	74.19	79.99	71.87	76.39	< 0.0001
90th	0.708	≤ 1.896	0.3611	78.05	58.06	71.11	66.67	69.43	0.0013
Mean	0.804	≤ 1.299	0.5869	78.05	80.65	84.21	73.54	79.17	< 0.0001
Median	0.779	≤ 1.28	0.6357	82.93	80.65	85.00	78.13	81.94	< 0.0001
f
25th	0.747	> 7.834	0.4579	78.05	67.74	76.19	70.00	73.61	< 0.0001
75th	0.844	> 27.279	0.6593	75.61	90.32	91.17	73.69	81.95	< 0.0001
90th	0.793	> 40.801	0.5382	73.17	80.65	83.33	69.45	76.39	< 0.0001
Mean	0.886	> 17.958	0.6924	85.37	83.87	87.50	81.26	84.72	< 0.0001
Median	0.856	> 13.992	0.6522	87.80	77.42	83.72	82.76	83.33	< 0.0001
Combined model	0.968	> 0.693	0.8458	87.80	96.77	97.29	85.71	91.67	< 0.0001

AUC: area under the curve; PPV: positive predictive value; NPV: negative predic-tive value

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