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Table 5 Correlations between TTLD ratio and quantitative CEUS parameters

From: Prognostic value of the tumor-to-liver density ratio in patients with metastatic colorectal cancer treated with bevacizumab-based chemotherapy. A post-hoc study of the STIC-AVASTIN trial

 

Day 0

Day 60

TTLD ≤ 0.6

TTLD > 0.6

p

TTLD ≤ 0.6

TTLD > 0.6

p

Blood volume parameters

 PE

Missing1

36.5 [7.9–217.2]

3

63 [13.6–189.9]

7

0.007

30.5 [6.4–238.7]

12

53.9 [14.4–242.0]

10

0.004

 WiAUC

Missing1

23.8 [3.7–53.0]

3

31.5 [8.1–151.7]

7

0.034

21.7 [5.6–56.7]

12

32.1 [11.5–103.2]

10

0.007

 WoAUC

Missing1

23.7 [3.0–63.3]

10

32.9 [8.1–196.5]

22

0.053

16 [5.9–51.2]

22

30.8 [15.0–168.9]

12

0.009

 AUC

Missing1

27.3 [3.1–56.7]

10

33.8 [9.3–184.2]

22

0.05

17.7 [5.8–50.3]

22

31.2 [14.0–146.8]

12

0.008

Blood flow parameters

 TTP

Missing1

65.8 [32.2–127.0]

3

59.8 [27.9–100]

7

0.65

72.9 [32.0–126.8]

12

63.1 [34.6–96.6]

10

0.22

 RT

Missing1

61.1 [26.4–130.6]

3

55.2 [25.3–109.2]

7

0.377

66.5 [25.5–120.4]

12

69.5 [31.1–103.3]

10

0.445

 FT

Missing1

61.9 [20.2–249.9]

10

56.8 [12.8–156.5]

22

0.815

70.2 [23.3–166.9]

22

53.2 [26.6–121.1]

12

0.556

 mTT

Missing1

78.8 [3.3–288.1]

3

62.1 [14.7–152.5]

7

0.521

88.2[14.2–425.5]

12

45.4 [7.0–425.5]

10

0.036

 WiR

Missing1

55.5 [9.8–642.6]

3

122.4 [19.3533.7]

7

0.018

41.1 [6.5–746.6]

12

105 [19.5–736.2]

10

0.009

 WoR

Missing1

55.3 [5.8–399.7]

10

112.4 [24.6–478.0]

22

0.053

36.9 [5.7–265.7]

22

109.8 [18.1–919.9]

12

0.019

 WiPI

Missing1

36.8 [8.3–200.3]

3

61.8 [13.1–170. 4]

7

0.008

32.6 [6.3–222.6]

12

54.6 [15.6–237.4]

10

0.005

  1. All values are relative to the healthy liver values (in percentage, determined as the lesion/reference value ratio *100), except1 for missing data reported as numbers
  2. PE Peak enhancement, WiAUC Wash-in area under the curve, WoAUC Wash-out area under the curve, AUC total area under the curve (= WiAUC + WoAUC), TTP Time to peak, RT Rising time, FT Fall time, mTT mean transit time, WiR Wash-in rate, WoR Wash-out rate, WiPI Wash-in Perfusion Index