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Table 2 Univariate and multivariate Cox analyses for OS of GC patients in the training cohort

From: Development and validation of a machine learning-based 18F-fluorodeoxyglucose PET/CT radiomics signature for predicting gastric cancer survival

Variables

Univariate Cox analysis

Multivariate Cox analysis

HR

HR.95 L

HR.95 H

P

HR

HR.95 L

HR.95 H

P

Age (> 65 vs. ≤65)

1.83

1.26

2.63

0.001*

1.71

1.16

2.53

0.007*

Gender (Female vs. Male)

1.17

0.80

1.69

0.417

-

-

-

-

BMI (Low vs. Normal)

1.47

0.98

2.23

0.064

-

-

-

-

BMI (High vs. Normal)

1.26

0.76

2.07

0.371

-

-

-

-

NRS2002(≥ 3 vs. <3)

1.41

0.81

2.45

0.219

-

-

-

-

Chemotherapy (Yes vs. No)

0.79

0.57

1.10

0.169

-

-

-

-

CA199 (Elevated vs. Normal)

2.86

2.05

3.99

P < 0.001*

1.41

0.99

2.01

0.055

CEA (Elevated vs. Normal)

2.08

1.51

2.86

P < 0.001*

1.67

1.19

2.35

0.003*

Surgery (Yes vs. No)

0.22

0.16

0.30

P < 0.001*

0.70

0.47

1.05

0.088

Clinical TNM (stage II vs. stage I)

3.58

1.01

12.70

0.048*

2.53

0.71

9.02

0.153

Clinical TNM (stage III vs. stage I)

9.02

2.80

29.02

P < 0.001*

3.65

1.10

12.15

0.035*

Clinical TNM (stage IV vs. stage I)

20.27

6.39

64.36

P < 0.001*

4.46

1.36

15.88

0.014*

PET RS

13.78

9.06

20.94

P < 0.001*

7.99

4.96

12.85

P < 0.001*

  1. *, P < 0.05; HR: Hazard ratio; L: Low; H: high; BMI: Body mass index; NRS 2002: Nutritional Risk Screening 2002; CA199: Carbohydrate antigen199; CEA: Carcinoembryonic antigen; TNM: Tumor-node-metastasis; PET RS: positron emission tomography radiomics scores