Table 2 Sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of CEUS interpretations for distinguishing the benign vs. malignant nature of FLLs compared to the reference standard for 2 experienced study radiologists and a radiology trainee when blinded to clinical history and unblinded to clinical history (except the lesional diagnosis)
From: Contrast enhanced ultrasound of liver lesions in patients treated for childhood malignancies
Blinded to Clinical Information | Unblinded to Clinical Information (exept lesional diagnosis) | |||||
|---|---|---|---|---|---|---|
Experienced Radiologist Reviewer 1 (95% CI) | Experienced Radiologist Reviewer 2 (95% CI) | Radiology Trainee (95% CI) | Experienced Radiologist Reviewer 1 (95% CI) | Experienced Radiologist Reviewer 2 (95% CI) | Radiology Trainee (95% CI) | |
Sensitivity | 77.8% (50.2–100) | 85.7% (42.1–99.6) | 0% (0–84.2) | 100.0% (100–100) | 100% (54.1–100) | 83.3% (35.9–99.6) |
Specificity | 86.8% (77.7–95.9) | 92.2% (81.1–97.8) | 91.5% (79.6–97.6) | 93.1% (86.6–99.6) | 94.0% (83.5–98.8) | 96.0% (86.3–99.5) |
Positive Predictive Value | 50.0% (23.8–76.2) | 60.0% (26.2–87.8 | 0% (0–60.2) | 60.0% (29.4–90.4) | 66.7% (30-92.5) | 71.4% (29.0–96.3) |
Negative Predictive Value | 95.8% (90.2–100) | 97.9% (88.9–100) | 95.6% (84.9–99.5) | 100.0% (100–100) | 100% (92.5–100) | 98.0% (89.2–100) |
Accuracy | 85.5% (76.7–94.3) | 91.4 (81-97.1) | 87.8% (75.2–95.4) | 93.8% (87.8–99.7) | 94.6% (85.1–98.9) | 94.6% (85.1–98.9) |