Contrast enhanced ultrasound of liver lesions in patients treated for childhood malignancies

Cancer Imaging

Table 3 CEUS enhancement pattern recorded by experienced study radiologist reviewer 1 and experienced radiologist reviewer 1, reviewer 2 and radiology trainee interpretations, and final histological diagnosis of 19 biopsied FLLs

CEUS enhancement pattern			Experienced Radiologist 1	Experienced Radiologist 2	Radiology Trainee	Histologic diagnosis
Arterial	Portal-venous	Delayed	Experienced Radiologist 1	Experienced Radiologist 2	Radiology Trainee	Histologic diagnosis
↑	↔	↓	Indeterminate	Malignant	Indeterminate	FNH
↑	↔	↔	Benign	Benign	Benign	Adenoma
↑	↔	↓	Benign	Indeterminate	Indeterminate	FNH
↑	↑	↑	Benign	Benign	Benign	FNH
↑	↔	↔	Benign	Indeterminate	Benign	Granulomatous inflammation
↑	↑	↑	Benign	Benign	Benign	Hepatocytes with Iron deposition
↔	↔	↔	Benign	Benign	Benign	Hepatitis with fibrosis and fungal infection
↑	↓	↓	Malignant	Malignant	Malignant	Metastatic Wilm’s tumor
↑	↓	↓	Malignant	Malignant	Malignant	Hepatocellular carcinoma
↔	↓	↓	Malignant	Malignant	Malignant	Hepatoblastoma
↓	↓	↓	Benign	Indeterminate	Malignant	Microabscess/ Necrotizing granuloma
↔	↓	↓	Malignant	Malignant	Indeterminate	CMV infection
↔ to ↑	↓	↓	Indeterminate	Malignant	Indeterminate	Metastatic adrenocortical carcinoma in patient with Li Fraumeni syndrome
↑	↓	↓	Malignant	Indeterminate	Indeterminate	Hepatocytes with iron deposition
↔ to ↓	↓	↓	Malignant	Indeterminate	Indeterminate	Lymphocytic and eosinophilic aggregates
↓	↓	↓	Indeterminate	Indeterminate	Malignant	Hepatoblastoma in patient with Beckwith Weidemann syndrome
↔ to ↑	↔	↔	Benign	Benign	Benign	FNH
↑	↔	↔	Indeterminate	Indeterminate	Benign	Hepatoblastoma in patient with trisomy 18
↑	↔	↓	Benign	Benign	Benign	Fatty change/possible FNH

ISSN: 1470-7330