Fig. 4

The performance of the clinical factors, CT reported results, radiomics-ITH model, and combined model for differentiation of benign from malignant renal lesions in the whole test cohort and in the test cohort with small renal lesion. ROC curves in the whole (A) and small renal lesion (D) test cohort; Calibration plot of observed vs predicated risk of malignant renal lesions in the whole (B) and small renal lesion (E) test cohort; Decision curve analysis for predicting malignant renal lesions in the whole (C) and small renal lesion (F) test cohort; Waterfall plot for predicated risk by the combined model in the whole (G) and small renal lesion (H) test cohort. The dashed lines from left to right indicates the cutoff values for 99% sensitivity, 95% sensitivity, 95% specificity, 99% specificity, respectively in the panel G and H. ITH: intratumoral heterogeneity; ROC: receive operating characteristic curves