Fig. 4

Metabolic Changes Shown in PET and MRS. Volumes of interest (VOIs) superimposed on images of a 62-year-old chemobrain patient received TRODAT-1 scan (A) and an age-matched control subject (B). Target region VOIs include the entire striatum, head of caudate nucleus, entire putamen, anterior putamen, and posterior putamen. Compared to the paired control (B), patients’ images (A) show decreased striatal uptake. Adopted from Vitor et al. [125]. (C) an example of the volumes of interest for multivoxel magnetic resonance spectroscopy (MRS) (Left) and the attained spectra (Middle and Right) from a breast cancer patient. The region of interest was placed in the right posterior cingulate cortex, and significantly lower NAA values were shown after treatment (Right) compared with before chemotherapy (Middle). Adopted from Tong et al. [126]