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Table 3 Univariate and multivariate survival analysis

From: Clinical significance of visual cardiac 18F-FDG uptake in advanced non-small cell lung cancer

Different variables

PFS

OS

Univariate

Univariate

Multivariate

MST

(days)

p-value

MST

(days)

p-value

HR

(95%CI)

p-value

Age

 < 70y

70y

189

209

0.701

NR

474.5

0.288

  

Gender

Male

Female

189

240

0.529

449

NR

0.074

  

PS

0–1

2–3

209

315

0.780

560

342

0.513

  

Histology

AC

Others

276

137

0.174

NR

234

0.023

1.372

(0.524–3.591)

0.523

NLR

High

Low

150

210

0.545

296

NR

0.007

2.745

(1.049–7.179)

0.032

PLR

High

Low

165

282

0.844

559

549

0.955

  

PNI

High

Low

240

178

0.701

560

449

0.494

  

GPS

0

1–2

270

145

0.107

NR

306

0.008

2.392

(0.916–6.245)

0.075

BMI

High

Low

208

225

0.432

523

NR

0.414

  

Cachexia

Yes

No

180

239

0.198

418

717

0.306

  

Cardiac

FDG (visual)

High

Low

268

165

0.196

NR

363

0.045

0.144

(0.024–0.855)

0.060

Cardiac SUVmax

High

Low

308

178

0.101

NR

378

0.015

0.088

(0.013–0.584)

0.028

Tumor SUVmax

High

Low

178

210

0.753

699

49

0.677

  

Tumor MTV

High

low

151

347

0.433

307

NR

0.112

  

Tumor TLG

High

Low

149

427

0.196

247

NR

0.019

1.529

(0.563–4.149)

0.401

First-line regimen

ICI

Non-ICI

182

270

0.742

781

418

0.350

  
  1. Abbreviations: MST median survival time (days), HR hazard ratio, 95% CI 95% confidence interval, NR not reached, SUVmax the maximum of standardized uptake value, MTV metabolic tumor volume, TLG total lesion glycolysis, ECOG PS eastern cooperative oncology group performance status, AC adenocarcinoma, non-AC non-adenocarcinoma, CRP C-reactive protein, PD-L1 programmed death ligand-1, NLR neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, SII systemic immune inflammation index, PNI prognostic nutrition index, ALI advanced lung cancer inflammation index, GPS Glasgow prognostic score, BMI body mass index, ICI immune checkpoint inhibitor, PFS progression-free survival, OS overall survival, bold type, statistically significance