Fig. 1

[¹⁸F]FDG PET/CT, CT and bone biospy images of bone metastases are shown. A 63-year-old man who represented with lytic metastatic lesions of spine with lung adenocarcinoma (A-C), the possible bone metastasis showed in CT and [¹⁸F]FDG PET/CT. The HE staining confirmed tumor metastasis. A 67-year-old man with no abnormal lesions was seen in CT (D), while a hypermetabolic bone lesion was showed in [¹⁸F]FDG PET/CT (E). Bone biospy of hypermetabolic site confirmed the metastatic lung tumor (F). A 79-year-old man with possible metastatic bone tumor was detected by CT(G), while the corresponding site showed no increased bone metabolism(H), the biopsy proved malignant. A 70-year-old man who represented with heterogenous density of the bone, the [¹⁸F]FDG PET/CT showed no abnormal lesions(J-K), pathological result showed ‘the tissue obtained was mainly bone marrow and fatty tissue and tumor cells were not seen(L)