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Table 2 Univariable Cox Proportional Hazards Regression Analyses for Overall Survival

From: Prognostic value of metabolic tumor volume on [18F]FDG PET/CT in addition to the TNM classification system of locally advanced non-small cell lung cancer

Variables

All patients

Clinical cohort

Trial cohort

 

HR

95%

CI

p value

HR

95%

CI

p value

HR

95%

CI

p value

Cohorta

1.526

2.341

0.994

0.053

        

Gender

 Female

reference category

reference category

reference category

 Male

1.233

0.837

1.816

0.289

2.065

0.773

5.517

0.148

1.089

0.714

1.662

0.692

Age

1.015

0.996

1.035

0.125

0.987

0.941

1.035

0.582

1.027

1.005

1.049

0.017

Histology

   

0.010

   

0.003

   

0.436

 AC

reference category

reference category

reference category

 SCC

1.805

1.209

2.696

0.004

5.214

1.777

15.302

0.003

1.325

0.859

2.044

0.203

 NOS/ others

1.819

1.092

3.028

0.022

6.228

2.037

19.048

0.001

1.268

0.696

2.31

0.437

Treatment

 Surgery

reference category

reference category

 

Chemoradiotherapy

2.037

1.068

3.884

0.031

1.786

0.806

3.955

0.153

    

UICC stage

   

< 0.001

   

0.031

   

0.005

 IIIa

reference category

reference category

reference category

 IIIb

1.519

0.999

2.310

0.050

0.949

0.410

2.201

0.904

1.686

1.015

2.800

0.044

 IIIc

2.612

1.625

4.200

< 0.001

4.218

1.331

13.363

0.014

2.499

1.432

4.361

0.001

PET parameters

 MTV(r)

1.419

1.168

1.724

< 0.001

1.676

1.116

2.516

0.013

1.316

1.049

1.651

0.018

 MTV

1.003

1.001

1.004

< 0.001

1.004

1.001

1.007

0.011

1.002

1.000

1.004

0.014

 TLG

1.000

1.000

1.000

0.005

1.000

1.000

1.001

0.024

1.000

1.000

1.001

0.074

 SULpeak

1.011

0.972

1.051

0.592

1.073

0.99

1.163

0.084

0.989

0.944

1.035

0.632

 SUVmax

1.005

0.980

1.029

0.714

1.042

0.991

1.096

0.108

0.992

0.963

1.021

0.565

n° of lesions

1.001

0.951

1.055

0.957

1.014

0.948

1.084

0.682

1.017

0.928

1.116

0.716

  1. a, trial cohort compared to clinical cohort. Bold values denote statistical significance
  2. Abbreviations: HR Hazard Ratio, CI Confidence Interval, NOS Not otherwise specified, PET Positron emission tomography, MTV(r) Radius of metabolic tumor volume, TLG Total lesion glycolysis, SULpeak Peak standardized uptake value corrected for lean body mass, SUVmax Maximum standardized uptake value, number