Variables | All patients | Clinical cohort | Trial cohort | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
HR | 95% | CI | p value | HR | 95% | CI | p value | HR | 95% | CI | p value | |
Cohorta | 1.526 | 2.341 | 0.994 | 0.053 | ||||||||
Gender | ||||||||||||
Female | reference category | reference category | reference category | |||||||||
Male | 1.233 | 0.837 | 1.816 | 0.289 | 2.065 | 0.773 | 5.517 | 0.148 | 1.089 | 0.714 | 1.662 | 0.692 |
Age | 1.015 | 0.996 | 1.035 | 0.125 | 0.987 | 0.941 | 1.035 | 0.582 | 1.027 | 1.005 | 1.049 | 0.017 |
Histology | 0.010 | 0.003 | 0.436 | |||||||||
AC | reference category | reference category | reference category | |||||||||
SCC | 1.805 | 1.209 | 2.696 | 0.004 | 5.214 | 1.777 | 15.302 | 0.003 | 1.325 | 0.859 | 2.044 | 0.203 |
NOS/ others | 1.819 | 1.092 | 3.028 | 0.022 | 6.228 | 2.037 | 19.048 | 0.001 | 1.268 | 0.696 | 2.31 | 0.437 |
Treatment | ||||||||||||
Surgery | reference category | reference category | ||||||||||
Chemoradiotherapy | 2.037 | 1.068 | 3.884 | 0.031 | 1.786 | 0.806 | 3.955 | 0.153 | ||||
UICC stage | < 0.001 | 0.031 | 0.005 | |||||||||
IIIa | reference category | reference category | reference category | |||||||||
IIIb | 1.519 | 0.999 | 2.310 | 0.050 | 0.949 | 0.410 | 2.201 | 0.904 | 1.686 | 1.015 | 2.800 | 0.044 |
IIIc | 2.612 | 1.625 | 4.200 | < 0.001 | 4.218 | 1.331 | 13.363 | 0.014 | 2.499 | 1.432 | 4.361 | 0.001 |
PET parameters | ||||||||||||
MTV(r) | 1.419 | 1.168 | 1.724 | < 0.001 | 1.676 | 1.116 | 2.516 | 0.013 | 1.316 | 1.049 | 1.651 | 0.018 |
MTV | 1.003 | 1.001 | 1.004 | < 0.001 | 1.004 | 1.001 | 1.007 | 0.011 | 1.002 | 1.000 | 1.004 | 0.014 |
TLG | 1.000 | 1.000 | 1.000 | 0.005 | 1.000 | 1.000 | 1.001 | 0.024 | 1.000 | 1.000 | 1.001 | 0.074 |
SULpeak | 1.011 | 0.972 | 1.051 | 0.592 | 1.073 | 0.99 | 1.163 | 0.084 | 0.989 | 0.944 | 1.035 | 0.632 |
SUVmax | 1.005 | 0.980 | 1.029 | 0.714 | 1.042 | 0.991 | 1.096 | 0.108 | 0.992 | 0.963 | 1.021 | 0.565 |
n° of lesions | 1.001 | 0.951 | 1.055 | 0.957 | 1.014 | 0.948 | 1.084 | 0.682 | 1.017 | 0.928 | 1.116 | 0.716 |