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Table 4 General characteristics of patients with HER2-negative breast cancer in prognostic analysis cohort

From: Comparative analysis of metabolic characteristics and prognostic stratification of HER2-low and HER2-zero breast cancer using 18F-FDG PET/CT imaging

 

Total numbers (n = 132)

Disease-free numbers (n = 116)

Disease-progressive numbers (n = 16)

Age, years (± SD)

 < 50

51 (38.6)

43 (37.1)

8 (50.0)

 ≥ 50

81 (61.4)

73 (62.9)

8 (50.0)

BMI‡

 < 25

85 (64.4)

76 (65.5)

9 (56.3)

 ≥ 25

47 (35.6)

40 (34.5)

7 (43.7)

T stage

 1/2

117 (88.6)

104 (89.7)

13 (81.3)

 3/4

15 (11.4)

12 (10.3)

3 (18.7)

Lymphatic metastasis

 Absent

42 (31.8)

39 (33.6)

3 (18.8)

 Present

90 (68.2)

77 (66.4)

13 (81.2)

Histologic grade

 Grade I/ II

67 (50.8)

60 (51.7)

7 (43.8)

 Grade III

65 (49.2)

56 (48.3)

9 (56.2)

Tumor histology

 Ductal

111 (84.1)

97 (83.6)

14 (87.5)

 Non-ductal

21 (15.9)

19 (16.4)

2 (12.5)

ER

 Negative

39 (29.5)

31 (26.7)

8 (50.0)

 Positive

93 (70.5)

85 (73.3)

8 (50.0)

PR

 Negative

51 (38.6)

42 (36.2)

9 (56.2)

 Positive

81 (61.4)

74 (63.8)

7 (43.8)

HER2

 Zero

50 (37.9)

42 (36.2)

8 (50.0)

 Low

82 (62.1)

74 (63.8)

8 (50.0)

Ki-67

 < 30%

42 (31.8)

38 (32.8)

4 (25.0)

 ≥ 30%

90 (68.2)

78 (67.2)

12 (75.0)

Molecular types

 Luminal

93 (70.5)

85 (73.3)

8 (50.0)

 Triple-negative

39 (29.5)

31 (26.7)

8 (50.0)

Treatment

 NAT

72 (54.5)

62 (53.4)

10 (62.5)

 Non-NAT

60 (45.5)

54 (46.6)

6 (37.5)

SUVmax

 

5.69 (3.58–9.04)

7.97 (4.16–16.05)

MTV

 

7.01 (4.10–12.38)

13.82 (4.40–22.05)

TLG

 

24.62 (10.56–45.14)

35.87 (16.32–209.96)

TLR

 

2.36 (1.46–3.68)

2.74 (1.63–5.97)

  1. Qualitative data are numbers followed by percentages in parentheses; continuous data are median followed by interquartile range (IQR) in parentheses, except for age. Hormone receptor (HR) has the same distribution as ER
  2. Abbreviations: HER2 human epidermal growth factor receptor 2, BMI body mass index, ER estrogen receptor, PR progesterone receptor, NAT neoadjuvant therapy, SUVmax maximum standardized uptake value, MTV metabolic tumor volume, TLG total lesion glycolysis, TLR tumor-to-liver SUV ratio