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Fig. 5 | Cancer Imaging

Fig. 5

From: Intratumoral and peritumoral CT radiomics in predicting anaplastic lymphoma kinase mutations and survival in patients with lung adenocarcinoma: a multicenter study

Fig. 5

Two instances of using the nomogram to predict ALK status in lung adenocarcinoma patients. (A) Case 1: A 63-year-old man with a diagnosis of adenocarcinoma, clinical IV stage, manifested as a well-circumscribed solid nodule in the left upper lobe with pleural indentation sign. Immunohistochemical (IHC) staining (×200) suggests the presence of granular cytoplasmic staining, confirming ALK (+). Vertical lines of each variable were drawn in the nomogram, and to obtain the GPTV3-Rad-score was 0.36. After summing all variables’ points the total was 78.74, and the graph revealed that the risk of ALK (+) was approximately 70%. (B) Case 2: A 52-year-old man with a diagnosis of adenocarcinoma, clinical I stage, manifesting as an ill-defined mixed-density nodule in the right upper lobe. IHC staining (×200) suggests no obvious stained cells, confirming ALK (-). Vertical lines of each variable were drawn in the nomogram. The GPTV3-Rad-score was 0.25. After summing all variables’ points the total was 25.00, and the graph revealed that the risk of ALK (+) was approximately 7%. ALK, anaplastic lymphoma kinase; GPTV, gross peritumoral tumor volume

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Cancer Imaging

ISSN: 1470-7330

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