Table 3 Prediction performance of Intratumor Heterogeneity Region based rad signatures

Clinic

Training

0. 830

0. 896

0. 8567 - 0. 9362

0. 810

0. 837

0. 627

0. 929

Radiomics

Training

0. 788

0. 879

0. 8405 - 0. 9171

0. 861

0. 764

0. 553

0. 942

Peri1mm

Training

0. 798

0. 856

0. 8071 - 0. 9054

0. 785

0. 803

0. 574

0. 917

Peri3mm

Training

0. 718

0. 824

0. 7713 - 0. 8771

0. 734

0. 712

0. 464

0. 888

Peri5mm

Training

0. 811

0. 874

0. 8311 - 0. 9170

0. 722

0. 841

0. 606

0. 899

Habitat

Training

0. 814

0. 891

0. 8539 - 0. 9274

0. 861

0. 798

0. 591

0. 944

Combined

Training

0. 846

0. 914

0. 8812 - 0. 9477

0. 658

0. 910

0. 712

0. 887

Clinic

Validation

0. 560

0. 636

0. 5184 - 0. 7534

0. 565

0. 559

0. 210

0. 861

Radiomics

Validation

0. 716

0. 819

0. 7436 - 0. 8952

0. 652

0. 730

0. 333

0. 910

Peri1mm

Validation

0. 761

0. 836

0. 7522 - 0. 9195

0. 739

0. 766

0. 395

0. 934

Peri3mm

Validation

0. 709

0. 761

0. 6523 - 0. 8706

0. 739

0. 703

0. 340

0. 929

Peri5mm

Validation

0. 754

0. 789

0. 6981 - 0. 8804

0. 565

0. 793

0. 361

0. 898

Habitat

Validation

0. 828

0. 877

0. 8141 - 0. 9407

0. 826

0. 829

0. 500

0. 958

Combined

Validation

0. 858

0. 904

0. 8455 - 0. 9618

0. 652

0. 901

0. 577

0. 926

Clinic

Testing

0. 597

0. 660

0. 4816 - 0. 8384

0. 625

0. 593

0. 172

0. 921

Radiomics

Testing

0. 612

0. 779

0. 6286 - 0. 9286

0. 750

0. 593

0. 200

0. 946

Peri1mm

Testing

0. 582

0. 738

0. 5550 - 0. 9217

0. 750

0. 559

0. 187

0. 943

Peri3mm

Testing

0. 522

0. 684

0. 4783 - 0. 8903

0. 625

0. 508

0. 147

0. 909

Peri5mm

Testing

0. 612

0. 609

0. 3707 - 0. 8475

0. 500

0. 627

0. 154

0. 902

Habitat

Testing

0. 687

0. 847

0. 7255 - 0. 9694

0. 875

0. 661

0. 259

0. 975

Combined

Testing

0. 881

0. 852

0. 7249 - 0. 9785

0. 000

1. 000

0. 000

0. 881