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Table 1 Main patients, surgical and pathological characteristics

From: Development and validation of machine learning models for predicting no. 253 lymph node metastasis in left-sided colorectal cancer using clinical and CT-based radiomic features

Characteristic

No. 253 LN negative

n = 2006

No. 253 LN positive

n = 112

p-value

Age, years

64.0 [56.0, 72.0]

63.0 [56.8, 70.2]

0.373

Sex, male

1263 (63.0%)

76 (67.9%)

0.345

CEA, high

735 (36.6%)

78 (69.6%)

< 0.001

CA19-9, high

219 (10.9%)

31 (27.7%)

< 0.001

CA24-2, high

419 (20.9%)

49 (43.8%)

< 0.001

Tumor site

  

< 0.001

Rectum

1388 (69.2%)

58 (51.8%)

 

Sigmoid colon

529 (26.4%)

50 (44.6%)

 

Descending colon

89 (4.44%)

4 (3.57%)

 

Distance from anal verge, cm

10.0 [6.00, 19.0]

15.0 [10.0, 20.0]

< 0.001

Endoscopic obstruction, yes

390 (19.4%)

50 (44.6%)

< 0.001

Synchronous liver metastasis, yes

62 (3.09%)

10 (8.93%)

0.004

Neoadjuvant, yes

40 (1.99%)

5 (4.46%)

0.086

Intraoperative No. 253 LN enlargement, yes

38 (1.89%)

21 (18.8%)

< 0.001

LCA ligation level, high

522 (26.0%)

49 (43.8%)

< 0.001

Gross type

  

0.002

Ulcerative

1382 (68.9%)

93 (83.0%)

 

Expanding/Infiltrative

624 (31.1%)

19 (16.9%)

 

Tumor differentiation

  

< 0.001

Well/moderately

1782 (88.8%)

79 (70.5%)

 

Poorly/undifferentiation

224 (11.2%)

33 (29.5%)

 

Pathological classification

  

0.003

Adenocarcinoma/Mucinous adenocarcinoma

2000 (99.7%)

109 (97.3%)

 

Signet ring adenocarcinoma/Undifferentiated carcinoma

6 (0.30%)

3 (2.68%)

 

Neural invasion

  

< 0.001

Yes

398 (19.8%)

66 (58.9%)

 

No

1543 (76.9%)

44 (39.3%)

 

Not reported

65 (3.24%)

2 (1.79%)

 

Lymphovascular invasion

  

< 0.001

Yes

254 (12.7%)

43 (38.4%)

 

No

1001 (49.9%)

1 (0.89%)

 

Not reported

751 (37.4%)

68 (60.7%)

 

AJCC pT classification

  

< 0.001

T1

170 (8.47%)

2 (1.79%)

 

T2

416 (20.7%)

3 (2.68%)

 

T3

1291 (64.4%)

81 (72.3%)

 

T4

129 (6.43%)

26 (23.2%)

 

AJCC pN classification

  

< 0.001

N0

1162 (57.9%)

0 (0.00%)

 

N1

578 (28.8%)

25 (22.3%)

 

N2

266 (13.3%)

87 (77.7%)

 
  1. Values are presented as median [lower quartile, upper quartile] or n (%)
  2. AJCC = American Joint Committee on Cancer; LN = lymph node; LCA = left colic artery
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