Table 3 Final selected radiomics features to identify HER2 expression status

HER2-over-expression vs. others

ct_original_shape_MajorAxisLength

pet_wavelet-LLL_firstorder_Skewness

pet_log-sigma-1-mm-3D_glcm_MCC

ct_wavelet-HHH_glszm_ZoneEntropy

ct_original_firstorder_Maximum

pet_original_glrlm_RunLengthNonUniformityNormalized

ct_wavelet-LHH_glszm_LargeAreaHighGrayLevelEmphasis

ct_log-sigma-1-mm-3D_glszm_LargeAreaHighGrayLevelEmphasis

HER2-low-expression vs. others

pet_wavelet-HHL_firstorder_Kurtosis

ct_wavelet-HHH_glszm_LargeAreaHighGrayLevelEmphasis

pet_wavelet-LHH_gldm_DependenceNonUniformityNormalized

pet_wavelet-LLL_firstorder_Skewness

pet_wavelet-HLH_glcm_JointEnergy

ct_wavelet-LLH_glcm_InverseVariance

ct_log-sigma-1-mm-3D_glszm_LargeAreaHighGrayLevelEmphasis

pet_wavelet-LHH_glszm_GrayLevelNonUniformity

ct_wavelet-LLH_glszm_SmallAreaLowGrayLevelEmphasis

pet_original_glszm_SmallAreaLowGrayLevelEmphasis

HER2-zero-expression vs. others

pet_wavelet-HHL_glcm_MaximumProbability

ct_wavelet-HHH_glszm_ZoneEntropy