Morphometric and radiomics analysis toward the prediction of epilepsy associated with supratentorial low-grade glioma in children

Table 1 Clinical demographics of pediatric supratentorial low grade glioma patients with or without epilepsy

Variables	with epilepsy (no. of patients)	without epilepsy (no. of patients)	p value
Patient number	23	25
Gender (male %)	15 (65.2%)	10 (40%)	0.15
Age at diagnosis (MRI) (years old, mean ± SD)	11.3 ± 6.3 years (range 1.0–18)	10.6 ± 5.8 years (range 1.0–18)	0.76
Age of seizure onset (years old, mean ± SD)	10.6 ± 7.8 years
Seizure frequency (monthly)	17 (73.9%)
Seizure duration (mins)	4.2 ± 5.3
Focal onset seizure	18 (78.2%)
Focal to FBTCS	5 (21.7%)
ASM polytherapy	11 (47.8%)
MRI characteristics
Side (right %)	8 (34.7%)	15 (60%)	0.15
Temporal lobe (main mass)	17 (73.9%)	4 (16%)	0.000088**
Basal ganglia involvement	6 (26.0%)	17 (68%)	0.008932**
Midbrain involvement	2 (8.6%)	10 (40%)	0.03*
Multiple lobes	6 (26.1%)	19 (76%)	0.0015**
Cyst formation	14 (60.9%)	8 (32%)	0.08626
Peritumor edema	11 (47.8%)	7 (28%)	0.26314
Hydrocephalus at diagnosis	1 (4.3%)	1 (4%)	0.50752
Tumor volume (ml)	34.61 ± 35.63	19.79 ± 21.57	0.085
Tumor pathology
Grade 1	13 (56.5%)	14 (56%)	0.79887
Grade 2	10 (43.4%)	11 (44%)	0.79887

ASM: anti-seizure medication; FBTCS: focal to bilateral tonic-clonic seizures; SD: standard deviation; Unpaired T-test or nonparametric Mann-Whitney (M-W) two-sample test / Chi-square test with Yate’s correction/Fisher exact test where appropriate. * p < 0.05; ** p < 0.01

ISSN: 1470-7330